Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study
Identifieur interne : 002031 ( Main/Exploration ); précédent : 002030; suivant : 002032Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study
Auteurs : G. V. Long [Australie] ; V. Atkinson [Australie] ; P. A. Ascierto [Italie] ; C. Robert [France] ; J. C. Hassel [Allemagne] ; P. Rutkowski [Pologne] ; K. J. Savage [Canada] ; F. Taylor [États-Unis] ; C. Coon [États-Unis] ; I. Gilloteau [États-Unis] ; H. B. Dastani [États-Unis] ; I. M. Waxman [États-Unis] ; A. P. Abernethy [États-Unis]Source :
- Annals of Oncology [ 0923-7534 ] ; 2016.
Abstract
In patients with advanced melanoma in the CheckMate 066 study, baseline health-related quality of life (HRQoL) with nivolumab was maintained over time, with statistically significant and clinically meaningful improvements in some exploratory analyses, and no HRQoL improvements with dacarbazine. Added to the survival benefit of nivolumab, the benefit-to-risk ratio favors nivolumab over dacarbazine.
Url:
DOI: 10.1093/annonc/mdw265
PubMed: 27405322
PubMed Central: 5035785
Affiliations:
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Ascierto</name><affiliation wicri:level="1"><nlm:aff id="mdw265_af3"><institution>Istituto Nazionale Tumori Fondazione Pascale</institution>,<addr-line>Napoli</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C." last="Robert">C. Robert</name><affiliation wicri:level="1"><nlm:aff id="mdw265_af4"><institution>Gustave-Roussy</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hassel, J C" sort="Hassel, J C" uniqKey="Hassel J" first="J. C." last="Hassel">J. C. Hassel</name><affiliation wicri:level="1"><nlm:aff id="mdw265_af5"><institution>University Hospital Heidelberg and National Center for Tumor Diseases</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rutkowski, P" sort="Rutkowski, P" uniqKey="Rutkowski P" first="P." last="Rutkowski">P. Rutkowski</name><affiliation wicri:level="1"><nlm:aff id="mdw265_af6"><institution>Sklodowska-Curie Memorial Cancer Center and Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Savage, K J" sort="Savage, K J" uniqKey="Savage K" first="K. J." last="Savage">K. J. 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Abernethy</name><affiliation wicri:level="1"><nlm:aff id="mdw265_af10"><institution>Duke Clinical Research Institute</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In patients with advanced melanoma in the CheckMate 066 study, baseline health-related quality of life (HRQoL) with nivolumab was maintained over time, with statistically significant and clinically meaningful improvements in some exploratory analyses, and no HRQoL improvements with dacarbazine. Added to the survival benefit of nivolumab, the benefit-to-risk ratio favors nivolumab over dacarbazine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Postow, Ma" uniqKey="Postow M">MA Postow</name></author><author><name sortKey="Callahan, Mk" uniqKey="Callahan M">MK Callahan</name></author><author><name sortKey="Wolchok, Jd" uniqKey="Wolchok J">JD Wolchok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggermont, Am" uniqKey="Eggermont A">AM Eggermont</name></author><author><name sortKey="Maio, M" uniqKey="Maio M">M Maio</name></author><author><name sortKey="Robert, C" uniqKey="Robert C">C Robert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robert, C" uniqKey="Robert C">C Robert</name></author><author><name sortKey="Long, Gv" uniqKey="Long G">GV Long</name></author><author><name sortKey="Brady, B" uniqKey="Brady B">B 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uniqKey="Swartz R">RJ Swartz</name></author><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y Xing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Revicki, Da" uniqKey="Revicki D">DA Revicki</name></author><author><name sortKey="Van Den Eertwegh, Aj" uniqKey="Van Den Eertwegh A">AJ van den Eertwegh</name></author><author><name sortKey="Lorigan, P" uniqKey="Lorigan P">P Lorigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grob, Jj" uniqKey="Grob J">JJ Grob</name></author><author><name sortKey="Amonkar, Mm" uniqKey="Amonkar M">MM Amonkar</name></author><author><name sortKey="Martin Algarra, S" uniqKey="Martin Algarra S">S Martin-Algarra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D Schadendorf</name></author><author><name sortKey="Amonkar, Mm" uniqKey="Amonkar M">MM Amonkar</name></author><author><name sortKey="Milhem, M" uniqKey="Milhem M">M Milhem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D Schadendorf</name></author><author><name sortKey="Amonkar, Mm" uniqKey="Amonkar M">MM Amonkar</name></author><author><name sortKey="Stroyakovskiy, D" uniqKey="Stroyakovskiy D">D Stroyakovskiy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D Schadendorf</name></author><author><name sortKey="Dummer, R" uniqKey="Dummer R">R Dummer</name></author><author><name sortKey="Hauschild, A" uniqKey="Hauschild A">A Hauschild</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickard, As" uniqKey="Pickard A">AS Pickard</name></author><author><name sortKey="Neary, Mp" uniqKey="Neary M">MP Neary</name></author><author><name sortKey="Cella, D" uniqKey="Cella D">D Cella</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Italie</li><li>Pologne</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>New Jersey</li></region></list><tree><country name="Australie"><noRegion><name sortKey="Long, G V" sort="Long, G V" uniqKey="Long G" first="G. 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Savage</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Taylor, F" sort="Taylor, F" uniqKey="Taylor F" first="F." last="Taylor">F. Taylor</name></region><name sortKey="Abernethy, A P" sort="Abernethy, A P" uniqKey="Abernethy A" first="A. P." last="Abernethy">A. P. Abernethy</name><name sortKey="Coon, C" sort="Coon, C" uniqKey="Coon C" first="C." last="Coon">C. Coon</name><name sortKey="Dastani, H B" sort="Dastani, H B" uniqKey="Dastani H" first="H. B." last="Dastani">H. B. Dastani</name><name sortKey="Gilloteau, I" sort="Gilloteau, I" uniqKey="Gilloteau I" first="I." last="Gilloteau">I. Gilloteau</name><name sortKey="Waxman, I M" sort="Waxman, I M" uniqKey="Waxman I" first="I. M." last="Waxman">I. M. Waxman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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